Amino Acid Supreme – 30g

Amino Acid Supreme™ is a source of essential amino acids for the maintenance of good health. Assists in the building of lean muscle when combined with regular training and a healthy balanced diet.


Amino Acid Supreme™ is a high potency, balanced, free-form essential amino acid formula in a great-tasting fruit punch flavoured powder for convenient and ecacious dosing. Because these amino acids are in their free form, they can be readily absorbed and utilized by the body. Amino acids are fundamental to a vast array of metabolic functions of the body. Insucient amino acid status may be due to digestive dysfunction, dietary and lifestyle factors, or from conditions that aect proper functioning of the stomach, pancreas, liver or small intestine.

Amino acids in their free form are immediately available for absorption and can be put to metabolic use much more readily and rapidly than amino acids contained in dietary protein. This may be especially beneficial for individuals with compromised digestive function, those recovering from physical trauma, and those (such as the elderly) who may have diculty consuming an adequate amount of complete protein. Alpha-ketoglutarate and vitamin B-6 (as pyridoxal-5- phosphate) are included for optimal absorption and ecacy.


• People whose diets are insucient in quality protein
• Patients with cachexia from chronic illness or GI malabsorption1-8
• Individuals who are in catabolic states due to stress or illness9-15
• Those recovering from surgery or tissue trauma16-20
• Individuals at risk of sarcopenia due to aging21-31
• Elderly individuals with suboptimal digestive function32-34
• People wanting better quality hair and nails35-37
• Patients who have confirmed amino acid deficiencies on metabolic testing


Amino acids play central roles as the building blocks of proteins and as intermediates in metabolism. The precise amino acid content and the sequence of the amino acids of a specific protein determine its biological activity. Proteins not only catalyze most of the reactions in living cells, they control virtually all cellular processes. Humans can produce 10 of the 20 amino acids; the others must be supplied through food or augmented by supplementation. Out of the 10 essential amino acids the body cannot synthesize, failure to obtain enough of even one will result in degradation of the body’s proteins, including structural proteins, potentially leading to inadequate levels of peptide hormones, enzymes, neurotransmitters, antibodies, and other protein based compounds. Unlike fat and starch, the human body does not store excess amino acids for later use, so amino acids must be consumed daily, or obtained through catabolic breakdown of body tissues containing amino acids, such as skeletal muscle.

The essential amino acids (EAAs), which must be obtained via diet or supplementation, are arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine.



Alpha-ketoglutarate is the keto acid produced by deamination of glutamate. It is a key intermediate in the energy-producing Krebs cycle, coming after the intermediate isocitrate and before succinyl CoA. Anaplerotic reactions, or supplementation, can replenish this cycle, helping to increase energy and stamina. Alpha-ketoglutarate is also one of the most important nitrogen transporters in metabolic pathways.

Alpha-ketoglutarate is transaminated, along with glutamine, to form the excitatory neurotransmitter glutamate. Glutamate can then be decarboxylated, via glutamic acid decarboxylase, into the inhibitory neurotransmitter GABA. This reaction requires vitamin B6 in the form of pyridoxal-5-phosphate or P-5-P. Adequate P-5-P was included in this formula to facilitate this, and other critical conversions.

Note that tryptophan is not included in Amino Acid SupremeTM in order to give the health care practitioner the ability to use Amino Acid SupremeTM regardless of the patient’s serotonin-related status and to allow the practitioner to add tryptophan (or Designs for Health’s 5-HTP SynergyTM or 5-HTP SupremeTM) on a case-by-case basis.


• Readily absorbable free-form essential amino acids
• Powder form for easy and ecacious dosing
• Great-tasting fruit punch flavour
• Zero grams sugar or caloric sweeteners; sweetened with stevia